Ngoi ra, Glutathione cn c kh nng ti to vitamin C v vitamin E trong c th, gip ngn nga tn thng t bo do gc t do v peroxit gy ra, ng thi chng oxy ha v loi b t bo da h hi, h tr hiu qu trong vic tr nm v tn nhang
Upon tamoxifen (TAM) application, Gpx4 RTEKO and Gpx4 HEPKO mice developed ferroptosis-driven acute kidney and liver dysfunction respectively, and consequently died
GSH exhibits multiple antioxidant actions, involving direct conjugation with free radicals such as ROS and reactive nitrogen species 46 and enzyme-mediated neutralization of free radicals, including GSH peroxidase (GPx), which detoxifies peroxides with GSH acting as an electron donor 47
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Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice